Synthesis of Medium Sized Rings from the Cycloadducts of 3,5-Dibromo-2-pyrone via a Radical Mediated Fragmentation Reaction

摘要

Medium sized macrocycles,natural or unnatural,are important synthetic targets because of a wide spectrum of their intriguing biological activity.Various synthetic strategies have been developed,most of which utilize ring closure of alpha,omega-bifunctional linear precursors.