Multi-species integrative biclustering

摘要

We describe an algorithm, multi-species cMonkey, for the simultaneous biclustering of heterogeneous multiplespeciesdata collections and apply the algorithm to a group of bacteria containing Bacillus subtilis, Bacillus anthracis,and Listeria monocytogenes. The algorithm reveals evolutionary insights into the surprisingly high degree of conservationof regulatory modules across these three species and allows data and insights from well-studied organismsto complement the analysis of related but less well studied organisms.