Pyridinolysis of Diisopropyl Chlorophosphate in Acetonitrile

摘要

Continuing the kinetic studies of the pyridinolyses of dimethyl [1: (MeO)2P(=O)Cl], diethyl [2: (EtO)2P(=O)Cl], and Y-aryl phenyl [4: (PhO)(YC6H4O)P(=O)Cl] chloro-phosphates, the nucleophilic suhstitution reactions of diisopropyl chlorophosphate (3) with substituted X-pyridines are investigated kinetically in acetonitrile at 35.0 ± 0.1 °C (Scheme 1) to gain further information into the reactivity and mechanism depending on the variation of the two ligands, R1O and R2O, where R1 and R2 are alkyl and/or phenyl (aryl). The numbering of the substrates of 1-4 follows the sequence of the size of the two ligands, R1O and R2O.