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The maintenance of genetic variability by mutatio in a polygenic character with linked loci

机译:通过具有连锁基因座的多基因性状中的突变来维持遗传变异性

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摘要

It is assumed that a character under stabilizing selection is determined genetically by n linked, mutable loci with additive effects and a range of many possible allelic effects at each locus. A general qualitative feature of such systems is that thegenetic variance for the character is independent of the linkage map of the loci, provided linkage is not very tight. A particular detailed model shows that certain aspects of the genetic system are moulded by stabilizing selection while others are selectively neutral. With reference to experimental data on characters of Drosophila flies, maize, and mice, it is concluded that large amounts of genetic variation can be maintained by mutation in polygenic characters even when there is strong stabilizing selection. The properties of the model are compared with those of heterotic models with linked loci.
机译:假定稳定选择下的一个字符是由n个连锁的,可变的基因座遗传决定的,这些基因座具有加性效应和在每个基因座上可能存在的许多等位基因效应。这种系统的一般定性特征是,如果链接不是很紧密,则字符的遗传方差与基因座的连锁图无关。一个特定的详细模型显示,遗传系统的某些方面是通过稳定选择来塑造的,而其他方面则是选择性中立的。参照果蝇,玉米和小鼠的性状的实验数据,可以得出结论,即使有很强的稳定选择,通过多基因性状的突变也可以维持大量的遗传变异。将模型的属性与具有链接基因座的异质模型的属性进行比较。

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