Tandem Michael-Wittig-Horner Reaction: One-Pot Synthesis of δ-Substituted α,β-Unsaturated Carboxylic Acid Derivatives - Application to a Concise Synthesis of (Z)- and (E)-Ochtoden-1-al

摘要

A new tandem Michael-Wittig-Horner reaction has been developed to produce in high yields δ-substituted α,β-unsaturated esters, amides and lactones. The reaction has been successfully applied to a concise synthesis of (E)- and (Z)-ochtoden-1-als, components of the male sex pheromone of boll weevil from 3-methylcyclohex-2-en-1-one.