Versatile launch pad for facile functionalization of cavitands

摘要

Suzuki-Miyaura cross-coupling reactions have been utilized for the derivatization of the upper-rim of cavitands, but unfortunately, only a relatively small number of suitable, inexpensive boronic acids are available. Herein, we report the synthesis and structure determination of a tetraboronic pinacolyl ester functionalized cavitand, which has been successfully employed in high-yielding coupling reactions with iodoarenes covering a range of functional groups, thereby demonstrating the versatility and chemoselectivity of this platform.