Carboplatin-based neoadjuvant treatment with peripheral blood stem cell and growth factor support in locally advanced cervical cancer patients with bulky metastatic lymph nodes.

摘要

Dear Editor, The presence of metastatic lymphnodes is one of the major factors negatively affecting survival in cervical carcinoma . These cases are commonly not included in chemoradiation or extended-field radiation protocols, and since the benefit extent of surgical removal of bulky nodes is to be clarified, neoadjuvant chemotherapy (NACT) followed by radical surgery (RS) could represent a valuable option. Cisplatin-based regimens may achieve a high response rate in different settings and an increase in the response rate has been shown in cervical cancer when doubling the dose of cisplatin . Carboplatin also has been shown to be active in cervical cancer , and its dose limiting toxicity (i.e. myelotoxicity) can be easily managed by growth factor (GF) and peripheral blood stem cell (PBSC) support.