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Lornoxicam: Pharmacology and usefulness to treat acute postoperative and musculoskeletal pain a narrative review

机译:氯诺昔康:药理学和治疗急性术后和肌肉骨骼疼痛的叙述

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摘要

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used for acute pain management. Lornoxicam is a nonselective NSAID for oral and intravenous administration. It has been available for human use since two decades and there is a growing body of evidence supporting its efficacy and tolerability for management of acute pain. Areas covered: Public domain literature around the clinical use of lornoxicam for acute pain management has been reviewed. Expert opinion: There are a growing number of clinical studies documenting lornoxicam effects for short-term treatment of acute postoperative pain following various surgical procedures. It has in the majority of comparative studies been shown superior as compared to paracetamol, non-inferior compared to other NSAIDs, and commonly similarly effective as standard clinical doses of opioids, but associated with better tolerability. Its effect on other acute pain, for example, headache, back pain, or sports injury is not well studied. Lornoxicam 8 mg twice daily is a seemingly effective and tolerable alternative NSAID for use as sole agent or as part of multimodal analgesia in adults. Available data does however not show any outstanding benefits or special risk. The general precautions with regard to the use of NSAIDs, the potential risks, for example, gastrointestinal bleeding and or cardiovascular side effects must be acknowledged.
机译:简介:非甾体类抗炎药(NSAIDS)通常用于急性疼痛治疗。氯诺昔康是用于口服和静脉内给药的非选择性NSAID。自从二十年以来,它已经可供人类使用,并且越来越多的证据支持其对急性疼痛的治疗的有效性和耐受性。涵盖领域:围绕氯诺昔康用于急性疼痛治疗的临床应用的公共领域文献已得到审查。专家意见:越来越多的临床研究证明氯诺昔康对各种手术方法后的急性术后疼痛的短期治疗具有疗效。在大多数比较研究中,与对乙酰氨基酚相比,它具有优越性,与其他非甾体抗炎药相比,劣等,且通常与阿片类药物的标准临床剂量相似,但具有更好的耐受性。它对其他急性疼痛(例如头痛,背痛或运动损伤)的作用尚未得到很好的研究。氯诺昔康8毫克,每日两次,是一种似乎有效且可耐受的非甾体抗炎药,可作为单独的药物或作为成年人多峰镇痛的一部分使用。但是,可用数据未显示任何突出的收益或特殊风险。必须认识到使用非甾体抗炎药的一般预防措施,潜在的风险,例如胃肠道出血和/或心血管副作用。

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