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首页> 外文期刊>Expert review of medical devices >Desynchronizing the abnormally synchronized neural activity in the subthalamic nucleus: a modeling study.
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Desynchronizing the abnormally synchronized neural activity in the subthalamic nucleus: a modeling study.

机译:解除丘脑底核中异常同步的神经活动的非同步性:一个模型研究。

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摘要

A mathematical model of a target area for deep brain stimulation was used to investigate the effects of electrical stimulation on pathologically synchronized clusters of neurons. In total, three newly developed stimulation techniques based on multisite coordinated reset and delayed feedback were tested and compared with a high-frequency stimulation method that is currently used as a standard stimulation protocol for deep brain stimulation. By modeling both excitatory and inhibitory actions of the electrical stimulation, we revealed the desynchronization impacts of the novel stimulation techniques. This contrasts with standard high-frequency stimulation, which failed to desynchronize the target population and whose inhibitory effects blocked all neuronal activity. We also explored the demand-controlled character of the proposed methods, and demonstrated that the amount of stimulation current required was considerably smaller than that for high-frequency stimulation. These novel stimulation methods appear to be superior to standard high-frequency stimulation techniques, and we propose the methods now be used for deep brain stimulation.
机译:用于深部脑刺激的目标区域的数学模型用于研究电刺激对神经元的病理同步簇的影响。总体上,测试了三种基于多站点协调重置和延迟反馈的新开发的刺激技术,并将其与当前用作深部脑刺激的标准刺激方案的高频刺激方法进行了比较。通过对电刺激的兴奋性和抑制性行为进行建模,我们揭示了新型刺激技术的失步影响。这与标准高频刺激相反,后者无法使目标人群失去同步,并且其抑制作用阻碍了所有神经元活动。我们还探索了所提出方法的需求控制特性,并证明所需的刺激电流量远小于高频刺激的电流量。这些新颖的刺激方法似乎优于标准的高频刺激技术,我们提出了现在可用于深部脑刺激的方法。

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