Re: Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen.

摘要

In this analysis, the authors report their results of multimodal 3-T magnetic resonance (MR) imaging and subsequent MR-guided biopsy of suspicious regions if detected (n = 68) in 71 men with at least two negative previous biopsies and prostate-specific antigen (PSA) >4.0 ng/ml. Mean age was 63 yr, median PSA was 13.0 ng/ml, and median prostate volume was 48.0 cm~3 With a median of four cores, the tumor-detection rate was 59% (40 of 68 cases), with the principal tumor location in the most ventral aspect of the transition zone (57%). Furthermore, the authors conclude that in 37 of 40 patients (93%), significant tumors were found (Gleason grade 4 or 5 in biopsy or prostatectomy specimen, pT3 or volume >0.5 cm~3 after surgery, PSA >10 ng/ml, PSA density >0.15 ng/ml per cubic centimeter in patients without subsequent prostatectomy). In addition, the findings were compared with a matched series of men with transrectal ultrasound (TRUS)-guided biopsies, revealing a significant higher detection rate for MR-guided biopsy.