Editorial comment on: localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity.

摘要

Penile erection is a complex neurovascular event that relies on vasodilatation of erectile tissues due to neural-and endothelial-derived nitric oxide (NO) released by activation of parasympathetic nerves on sexual stimula tion and by further shear-stress-dependent stimulation of the cavernous endothelial lining [1], Cannabinoids are signaling molecules derived from the cell membranes of nerves, blood cells, and endothelial cells that have earlier been related to erectile function and male sexual behavior [2,3]. Endogenous and exogenous cannabinoids were initially thought to regulate erectile function and sexual activity through the modulation of neural transmission of brain oxytocynergic neurons from paraventricular nucleus [2]. Endocannabinoid CB1 receptors, however, have recently also been found to regulate peripheral nitrergic neurotransmission in the rat corpus cavernosum (CC) [4].