Re: Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles

摘要

The authors analysed the value of metabolomic profiles to predict biochemical progression (BP) risk in patients with prostate cancer (PCa) submitted to radical prostatectomy (RP). They retrospectively analysed 183 PCa cases submitted to RP, using an intact-tissue magnetic resonance spectroscopy (MRS) method. A high-resolution, magic-angle, spinning proton MRS was used to investigate a metabolomic analysis of still-intact prostate tissue. This method allows study of chemical metabolites in their native state and control of intact-tissue spectra, preserving the tissue for pathologic analysis. In this study, metabolomic profiles analysed by MRS could differentiate cases of PCa with BP after RP from clinical and pathologic-stage matched cases without BP.