The effects of temporary ischemia in partial nephrectomy on renal functional outcomes: How can effects best be estimated, and can they be mitigated?

摘要

Partial nephrectomy is currently regarded as the standard of care for good surgical candidates with organ-confined, anatomically amenable renal masses. Over the last decade, the benefits of partial nephrectomy compared to radical nephrectomy [1] and the correlation between chronic kidney disease and risk of cardiovascular events and death [2] have been well established. More recently, the topic of renal ischemia and other factors potentially affecting renal function have been the focus of debate [3] and intense clinical and laboratory research.