To what extent can we predict prostate cancer lymph node involvement?

摘要

In this issue of European Urology, Godoy et al from the Memorial Sloan-Kettering Cancer Center (MSKCC) validate a previously developed preoperative nomogram to predict lymph node involvement (LNI) of prostate cancer at pelvic lymph node dissection (PLND) during radical prostatectomy (RP) [1 ]. These earlier data were derived from six institutions between 1985 and 2000 [2] and consisted of >5000 men, as opposed to the current study data, which are exclusively from MSKCC during 2000-2008 and include >3000 men. The accuracy of the original nomogram was 76% (area under the curve [AUC]: 0.76) compared to a level of 74% (AUC: 0.74) using the Partin tables [2], Both models use prostate-specific antigen (PSA), biopsy Gleason score, and clinical T stage.