Simple measurements for prediction of drug release from polymer matrices - Solubility parameters and intrinsic viscosity

Madsen Claus G.; Skov Anders; Baldursdottir Stefania; Rades Thomas; Jorgensen Lene; Medlicott Natalie J.

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Simple measurements for prediction of drug release from polymer matrices - Solubility parameters and intrinsic viscosity

机译：预测聚合物基质中药物释放的简单方法-溶解度参数和特性粘度

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Purpose: This study describes how protein release from polymer matrices correlate with simple measurements on the intrinsic viscosity of the polymer solutions used for casting the matrices and calculations of the solubility parameters of polymers and solvents used.

机译：目的：本研究描述了聚合物基质中蛋白质的释放与用于铸造基质的聚合物溶液的特性粘度的简单测量以及所用聚合物和溶剂的溶解度参数计算之间的关系。

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《European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V》 |2015年第null期|共7页
作者
Madsen Claus G.; Skov Anders; Baldursdottir Stefania; Rades Thomas; Jorgensen Lene; Medlicott Natalie J.;
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正文语种 eng
中图分类药学;
关键词
Therapeutic proteins; Polymer matrices; Drug delivery systems; Bovine serum albumin; Protein release; Medical device;

机译：治疗性蛋白质;聚合物基质;药物递送系统;牛血清白蛋白;蛋白质释放;医疗器械;

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1. Simple measurements for prediction of drug release from polymer matrices - Solubility parameters and intrinsic viscosity [J] . Madsen Claus G., Skov Anders, Baldursdottir Stefania, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2015,第Null期

机译：预测聚合物基质中药物释放的简单方法-溶解度参数和特性粘度
2. Prediction of drug solubility in an acrylate adhesive based on the drug-polymer interaction parameter and drug solubility in acetonitrile [J] . Li JW., Masso JJ., Guertin JA. Journal of Controlled Release: Official Journal of the Controlled Release Society . 2002,第2期

机译：基于药物-聚合物相互作用参数和药物在乙腈中的溶解度预测丙烯酸酯粘合剂中的药物溶解度
3. Formulation of a poorly water-soluble drug in sustained-release hollow granules with a high viscosity water-soluble polymer using a fluidized bed rotor granulator [J] . Asada Takumi, Yoshihara Naoki, Ochiai Yasushi, International Journal of Pharmaceutics . 2018,第1a2期

机译：使用流化床转子造粒机的高粘度水溶性聚合物在持续释放中空颗粒中进行较差的水溶性药物的制剂
4. Comparison of drug release prediction from HPMC matrices, effects of polymer concentration and physicochemical properties of drug by using equation and Artificial Neural Networks [C] . MAHSHID MOHAMMADI, ABDOLHOSSEIN QADERI Latest advances in information science, circuits and systems . 2012

机译：使用方程式和人工神经网络比较HPMC基质中药物释放预测，聚合物浓度和药物理化性质的影响
5. Hydrophilic polymer viscosities on gastric retentive drug delivery systems of Gabapentin sustained release tablets [D] . Johns, Benjamin Onnoonay 2010

机译：加巴喷丁缓释片在胃滞留给药系统上的亲水性聚合物粘度
6. A Unified Mathematical Model for the Prediction of Controlled Release from Surface and Bulk Eroding Polymer Matrices [O] . Sam N. Rothstein, William J. Federspiel, Steven R. Little -1

机译：预测表面和本体腐蚀聚合物基体控制释放的统一数学模型
7. The use of solubility parameters to predict the behaviour of a co-crystalline drug dispersed in a polymeric vehicle. Approaches to the prediction of the interactions of co-crystals and their components with hypromellose acetate succinate and the characterization of that interaction using crystallographic, microscopic, thermal, and vibrational analysis. [O] . Isreb Abdullah 2012

机译：使用溶解度参数来预测分散在聚合物载体中的共结晶药物的行为。预测共结晶及其组分与醋酸羟丙甲纤维素琥珀酸酯的相互作用的方法，以及使用晶体学，微观，热和振动分析表征相互作用的方法。

Simple measurements for prediction of drug release from polymer matrices - Solubility parameters and intrinsic viscosity

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