SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG RELEASE

摘要

The present invention relates to a method for modulating delivery of a drug by adjusting the saturation concentration of the drug in a transdermal composition for use in the skin, wherein the transdermal composition comprises a mixture of polymers having different solubility parameters from each other. Therefore, the transmittance through the skin of the predetermined drug can be obtained. In one embodiment, the skin composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The skin composition may be provided by a number of known drug-containing adhesive preparation methods, wherein the drug-containing adhesive preparation method involves removing the solvent after mixing the polymers, the drug, and the additional components in the solution. Include.