Trinuclear Half-Sandwich Ru-II, Rh-III and Ir-III Polyester Organometallic Complexes: Synthesis and in vitro Evaluation as Antitumor Agents

摘要

Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either 2-pyridinecarboxaldehyde or salicylaldehyde were used to synthesise bidentate trimeric ester ligands. The trimeric ester ligands were used to prepare a new series of trinuclear polyester organometallic complexes by using the dimeric precursors, [Ru((6)-p-iPrC(6)H(4)Me)Cl-2](2), [Rh(C5Me5)Cl-2](2) or [Ir(C5Me5)Cl-2](2). The Schiff base ligands act as bidentate donors to each metal. All compounds were characterised by NMR and IR spectroscopy, elemental analysis and EI/ESI mass spectrometry. Model mononuclear analogues were prepared, and the molecular structures of selected compounds were determined by single-crystal X-ray diffraction analysis. The mono- and trimeric ligands and the metal complexes were evaluated for inhibitory effects against the human ovarian cancer cell lines, A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant), and the model human skin fibroblast cell line, KMST-6.