首页> 外文期刊>European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie >Membrane dynamics and fusion at late endosomes and vacuoles - Rab regulation, multisubunit tethering complexes and SNAREs
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Membrane dynamics and fusion at late endosomes and vacuoles - Rab regulation, multisubunit tethering complexes and SNAREs

机译:晚期内体和液泡的膜动力学和融合-Rab调节,多亚基束缚复合体和SNARE

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摘要

Membrane fusion at late endosomes and vacuoles depends on a conserved machinery, which includes Rab GTPases, their binding to tethering complexes and SNAREs. Fusion is initiated by the interaction of Rabs with tethering complexes. At the endosorne, the CORVET complex interacts with the Rab5 GTPase Vps21, whereas the homologous HOPS complex binds the Rab7-like Ypt7 at the late endosome and vacuole. Activation of Ypt7 requires the recruitment of the Mon1-Ccz1 complex to the late endosome, which occurs via the CORVET complex. The interaction of Rab and the tethering complex is followed by the assembly of SNAREs, which leads to bilayer mixing. In this review, we will summarize our current knowledge on the mechanisms and regulation of endosome and vacuole membrane dynamics, and their role in organelle physiology
机译:晚期内体和液泡的膜融合取决于保守的机制,其中包括Rab GTPases,它们与束缚复合物和SNARE结合。融合是由Rabs与束缚复合物的相互作用引发的。在内胚层,CORVET复合物与Rab5 GTPase Vps21相互作用,而同源HOPS复合物在晚期内体和液泡处结合Rab7样的Ypt7。 Ypt7的激活需要将Mon1-Ccz1复合物募集到晚期内体,这是通过CORVET复合物发生的。 Rab和束缚复合物的相互作用之后,是SNARE的组装,这导致双层混合。在这篇综述中,我们将总结我们目前关于内体和液泡膜动力学的机制和调控及其在细胞器生理中的作用的知识。

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