Synthesis, characterization, cytotoxicity of mixed ligand complexes of palladium(II) with dipyrido[3,2-d:2 ',3 '-f]quinoxaline/dipyrido[3,2-a:2 ',3 '-c](6,7,8,9-tetrahydro)phenazine and 4-toluensulfonyl-L-amino acid dianion

摘要

Ten novel palladium(II) complexes with dipyrido[3,2-d:2',3'-f]quinoxaline (Dpq)/dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazine (Dpqc) and 4-toluensulfonyl-L-amino acid dianion, [Pd(Dpq)(TsvalNO)]center dot H2O (1a), [Pd(Dpq)(TsileNO)]center dot H2O (1b), [Pd(Dpq)(TsserNO)] (1c), [Pd(Dpq)(TsthrNO)]center dot 1.5H(2)O (1d), [Pd(Dpq)(TsleuNO)]center dot 0.5H(2)O (1e), [Pd(Dpq)(TspheNO)] (1f) [Pd(Dpqc)(TsvalNO)] (2a), [Pd(Dpqc)(TsileNO)] (2b), [Pd(Dpqc)(TsserNO)]center dot H2O (2c) and [Pd(Dpqc)(TsthrNO)]center dot 0.5H(2)O (2d) have been synthesized and characterized by elemental analysis, IR, IN, H-1 NMR and mass spectrometry techniques. Crystal structure of the complex 1f has been determined by X-ray diffraction. The cytotoxicity was tested by MTT assay. The results indicated that the complexes 1a and 2a showed better cytotoxicity than cisplatin against MCF-7. The complex 1e had higher cytotoxicity than cisplatin against K562. Both the N donating ligands and the amino acid have important effects on the cytotoxicity. (c) 2014 Elsevier Masson SAS. All rights reserved.