PALLADIUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND APPLICATIONS IN CANCER TREATMENT

摘要

Palladium (II) N-heterocyclic carbene (NHC) complexes which are stable in the presence of biological thiols. A representative complex, [Pd (C^N^N) (N, N'-nBu ₂NHC) ] (CF ₃SO ₃) (Pd1d, HC^N^N ＝ 6-phenyl-2, 2'-bipyridine, N, N'-nBu ₂NHC＝N, N'-di-n-butylimidazolium), displays potent killing activity toward cancer cell lines but is less cytotoxic toward normal human fibroblast cell lines.