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PLATINUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND AND PINCER LIGANDS, SYNTHESIS, AND THEIR APPLICATIONS IN CANCER TREATMENT
PLATINUM (II) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND AND PINCER LIGANDS, SYNTHESIS, AND THEIR APPLICATIONS IN CANCER TREATMENT
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机译:含N-杂环碳原子和钳子配体的铂(II)配合物,合成及其在癌症治疗中的应用
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摘要
Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
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