Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: Report of two cases with no evidence of systemic disease

摘要

Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma (AECTCL) is a rare, provisional entity in the 2008 WHO classification [1]. Our new cases represent clinical variants of the disease without systemic involvement that have not been published among the previously reported fewer than 50 cases [2]. A 60 year-old man was referred to our center with a three year history of bluish-red macules and erythematous plaques on the legs and trunk. During 33 months follow-up, three biopsies were taken. The disease showed progression from pagetoid epidermal infiltration at presentation {figure 1A), through an intermediate phase represented by a lichenoid dermal infiltrate, to a diffuse tumorous lesion. The morphology, immunophenotype (figure IB) and prominent epidermotropism of the tumor cells were identical in all biopsies.