Eradication of Helicobacter pylori infection might have a positive impact on subpopulations with endoscopic gastro-oesophageal reflux disease

摘要

In their meta-analysis, Xie et al. [1] concluded that Helicobacter pylori {Hp) infection (Hp-I) shows a negative association with endoscopic gastro-oesophageal reflux disease (GORD) development, and its eradication may be an inciting risk factor for GORD, especially in Asian populations; therefore, Hp eradication among the general population is inadvisable. However, this conclusion might represent only one side of the coin; in a large retrospective cohort study of 20918 Chinese individuals, Wu et al. [2] concluded that the Hp-I decline within a 7-year period coincides with the substantial drop in duodenal ulcer and the increase in GORD incidence; however, GORD is rarely triggered after Hp eradication.