Adjusting the starting dose of telaprevir according to renal function decreases adverse effects and affects the sustained virological response rate

Morihara Daisuke; Watanabe Hiroshi; Takata Kazuhide; Iwashita Hideyuki; Tsuchiya Naoaki; Kunimoto Hideo; Kuno Shizuka; Fukunaga Atsushi; Yotsumoto Kaoru; Tanaka Takashi; Sakurai Kunitoshi; Hirano Genryu; Yokoyama Keiji; Nishizawa Shinya; Yoshikane Makoto; Anan Akira; Takeyama Yasuaki; Kitamura Yuji; Iwata Kaoru; Irie Makoto; Shakado Satoshi; Sohda Tetsuro; Sakisaka Shotaro

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Adjusting the starting dose of telaprevir according to renal function decreases adverse effects and affects the sustained virological response rate

机译：根据肾脏功能调整特拉匹韦的起始剂量可减少不良反应并影响持续的病毒学应答率

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Background Telaprevir (TVR) plays a major role in renal damage and anemia associated with TVR/pegylated interferon/ribavirin therapy for chronic hepatitis C. Adjusting the TVR starting dose may reduce these adverse effects. We aimed to determine whether adjusting the starting dose according to renal function reduces TVR-associated renal damage and anemia and affects the sustained virological response (SVR).

机译：背景特拉帕韦（TVR）在与TVR /聚乙二醇化干扰素/利巴韦林治疗慢性丙型肝炎相关的肾损害和贫血中起主要作用。调整TVR起始剂量可减少这些不良反应。我们旨在确定根据肾脏功能调整起始剂量是否能减少与TVR相关的肾脏损害和贫血，并影响持续的病毒学应答（SVR）。

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《European journal of gastroenterology and hepatology》 |2015年第1期|共10页
作者
Morihara Daisuke; Watanabe Hiroshi; Takata Kazuhide; Iwashita Hideyuki; Tsuchiya Naoaki; Kunimoto Hideo; Kuno Shizuka; Fukunaga Atsushi; Yotsumoto Kaoru; Tanaka Takashi; Sakurai Kunitoshi; Hirano Genryu; Yokoyama Keiji; Nishizawa Shinya; Yoshikane Makoto; Anan Akira; Takeyama Yasuaki; Kitamura Yuji; Iwata Kaoru; Irie Makoto; Shakado Satoshi; Sohda Tetsuro; Sakisaka Shotaro;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
anemia; pegylated interferon; renal impairment; ribavirin; telaprevir;

机译：贫血;聚乙二醇干扰素;肾功能损害;利巴韦林;特拉帕韦;

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1. Adjusting the starting dose of telaprevir according to renal function decreases adverse effects and affects the sustained virological response rate [J] . Morihara Daisuke, Watanabe Hiroshi, Takata Kazuhide, European journal of gastroenterology and hepatology . 2015,第1期

机译：根据肾脏功能调整特拉匹韦的起始剂量可减少不良反应并影响持续的病毒学应答率
2. Sustained Virologic Response Rates With Telaprevir-Based Therapy in Treatment-Naive Patients Evaluated by Race or Ethnicity [J] . Flamm Steven L., Muir Andrew J., Fried Michael W., Journal of clinical gastroenterology . 2015,第4期

机译：基于种族或族裔评估的未接受过治疗的患者，采用特拉普韦韦疗法的持续病毒学应答率
3. Sustained virological response with telaprevir in 1078 patients with advanced hepatitis C: The international telaprevir access program. [J] . Massimo Colombo, Simone Strasser, Christophe Moreno, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2014,第5期

机译：使用telaprevir对1078例晚期丙型肝炎患者进行持续的病毒学应答：国际telaprevir访问计划。
4. Oral Mycophenolate Mofetil Dose Escalation Trial Assessing Adverse Effects and Pharmacodynamic Responses in Normal Dogs (Abstract P14) [C] . Conference of the American College of Veterinary Internal Medicine (ACVIM) . 2017

机译：口服霉霉素Mofetil剂量升级试验评估正常狗的不利影响和药物动力学反应（摘要P14）
5. Baseline Toronto HCC Risk Index (THRI) and Albumin Predict Low Risk of Hepatocellular Carcinoma (HCC) after Sustained Virological Response (SVR) in HCV Infection [D] . Lau, Jason. 2019

机译：基线多伦多HCC风险指数（THRI）和白蛋白预测HCV感染持续病毒响应（SVR）后肝细胞癌（HCC）的低风险
6. Prediction of Sustained Virological Response to Telaprevir-Based Triple Therapy Using Viral Response within 2 Weeks [O] . Hideyuki Tamai, Ryo Shimizu, Naoki Shingaki, 2014

机译：使用病毒反应在2周内预测对基于Telaprevir的三联疗法的持续病毒学反应
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机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。
8. Functional Consequences of Prenatal Methylmercury Exposure: Effects on Renal and Hepatic Responses to Trophic Stimuli and on Renal Excretory Mechanisms [R] . Slotkin, T. A. , Kavlock, R. J. , Cowdery, T. , 1986

机译：产前甲基汞暴露的功能后果：对营养刺激的肾脏和肝脏反应以及肾脏排泄机制的影响

Adjusting the starting dose of telaprevir according to renal function decreases adverse effects and affects the sustained virological response rate

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