Detection of human bocavirus in Asturias, Northern Spain

摘要

Viral respiratory tract infections cause a substantial amount of illness and death in children worldwide. The so-called respiratory viruses that include respiratory syncytial virus (RSV), influenza virus A (IA) and influenza virus B (IB), human parainfluenza viruses (PIV), adenovirus, coronavirus, rhinovirus, the recently discovered human metapneumovirus (hMPV), and several coronaviruses (SARS, NL63, HKu1) likely account for a majority of respiratory tract illnesses. However, in a substantial proportion of respiratory tract infections, no etiologic agent is detected, even when sensitive detection methods, such as a polymerase chain reaction (PCR), are used. This finding suggests that unidentified pathogens may be circulating and causing disease in children. Recently, a new member of the Parvoviridae family, the human bocavirus (HBoV), has been cloned from nasopharyngealaspirates of children with acute respiratory infection (ART) in Sweden . In spite of the few reports published, HBoV appears to be verycommon. Thus, it has been detected in 1.5%-11.3% of individuals with ARI in Europe, the United States, Canada, Asia, South Africa, and Australia. The clinical manifestation includes cough, fever, rhinitis, nasal congestion, myalgia, respiratory difficulty, bronchiolitis, and pneumonia [1-10].