131I gastric uptake with and without omeprazole in patients undergoing radioiodine therapy for differentiated thyroid carcinoma.

摘要

The European Association of Nuclear Medicine (EANM) Therapy Committee guidelines for radioiodine therapy (RAIT) for differentiated thyroid cancer recommend that "the stomach lining should be protected by liberal oral hydra-tion, and use of medication, e.g. H2-blockers, also may be helpful" [1]. Histamine H2 blockers such as cimetidine and ranitidine block secretion from the cells and increase gastric mucosal uptake. Proton pump inhibitors such as omeprazole (OM) are also commonly prescribed to alleviate stomach complaints. OM, which has effects similar to those of H2 blockers, is an inhibitor of gastric acid secretion,