Summary of GIGYF2 studies in Parkinson's disease: the burden of proof.

摘要

The past decade has been an exciting time for investigators involved in genetic research in Parkinson's disease (PD). At least six pathogenic genes and numerous disease-loci and risk variants have been reported to be associated with both familial and/or sporadic forms of the disease [1-3]. Some have described these breakthroughs as tantamount to an 'embarrassment of riches' as every single discovery adds further clues to unraveling its pathophysiology and provide an enormous opportunity for research.Thus reports of new causative genes invariably bring considerable delight and interest for clinicians, geneticists, and scientists.