Optimal duration of prophylactic antimicrobial administration and risk of postoperative infectious events in thoracic esophagectomy with three-field lymph node dissection: short-course versus prolonged antimicrobial administration

摘要

For prevention of surgical site infections, the current guidelines of Center of Disease Control recommend the maintenance of therapeutic levels of prophylactic antimicrobial agents throughout operations and, at most, for a few hours after incision closure. However, in literature supporting these recommendations, most reports have described combinations of various types of surgical procedures. Consequently, the optimal duration of prophylactic antimicrobial administration in esophagectomy with three-field lymph node dissection has not been fully addressed.