Ecotoxicological Characterisation and Classification of Existing Chemicals/Examples from the ICCA HPV Initiative and comparison with other existing chemicals

摘要

Goal, Scope and Background. In 1998, the International Council of Chemical Associations (ICCA) launched a global initiative to investigate more than 1,000 HPV chemicals (High Production Volume, > = 1,000 t/a) within the refocused OECD HPV Chemicals Programme. Up to the OECD SIDS Initial Assessment Meeting in April 2004 (SIAM 18) 147 ICCA dossiers (ca. 230 CAS-No) have been assessed based on a harmonised data set. The environmental profile and an ecotoxicological characterisation of these chemicals are presented here. Data for acute aquatic toxicity were correlated among each other, as well as data for fish (LC_(50), LD_(50)) and rodents (LD_(50)). The data for acute aquatic toxicity are compared with other existing chemicals. Methods. Data of the ICCA HPV chemicals from the OECD SIAM 11-18 are presented for: log K_(OW) (as an indicator for bioaccumulation potential), biodegradation, acute aquatic toxicity and availability of long-term toxicity data. Correlation analysis was performed with log transformed data and a linear regression model was fitted to the data, if a significant correlation was found. Acute toxicity for fish and acute oral toxicity for rodents were correlated on a molar basis. Acute aquatic toxicity of the chemicals is compared with data from BUA reports 1-234 and a random EINECS sample (Knacker et al. 1995). Results and Discussion. According to the dossier information, 71 of the 147 ICCA chemicals are not 'readily biodegradable', 21 have a log K_(OW) > = 3, and 44 are 'toxic' (LC/EC_(50) < 10 mg/L) or 'very toxic' (LC/EC_(50) < 1 mg/L) to aquatic organisms. For 77, only the base set (acute fish, Daphnia and algae) is available, for the rest at least one long-term test (fish or Daphnia) is available and three tests for a mere 14 others. Based on the data presented, the SIAM gives recommendations for Environment and Human Health. 22 chemicals have been identified as a 'candidate for further work' for Environment and 16 for Human Health. The highest correlation coefficient was obtained correlating fish and Daphnia (r~2 = 0.79). LC_(50) (fish) is significantly correlated with LD_(50) (rodent), but data are widely scattered. The correlation is not improved after transforming LC_(50) (fish) to LD_(50) (fish), using BCF QSAR. Based on acute aquatic toxicity, 25.1percent of the chemicals from the BUA reports 1-234 are classified as 'very toxic' (LC/EC_(50) < = 1 mg/L). This proportion is 2.5-fold higher than the ICCA HPV chemicals and 1.4-fold higher than the random EINECS sample. Conclusions. Correlation coefficients for aquatic toxicity data are rather uniform (0.57-0.79) compared with literature data, but also the best correlation was observed between fish and Daphnia. Because the scatter around the regression lines is still considerable, simple predictions of ecotoxicity between species are not possible. Correlation of LC_(50) (fish) and LD_(50) (rodent) indicates that toxicity is different. Surprisingly, the correlation offish and rodent toxicity is not improved by transforming LC_(50) values to internal LD_(50) s. The selection of ICCA chemicals by market significance (production volume) leads to a classification of toxicity, which is more comparable to a random sample of EINECS chemicals than to German BUA chemicals. The latter were chosen for concern (for Environment or Human Health). Recommendations and Outlook. Of 147 dossiers assessed between SIAM 11-18, ca. 75 percent were sponsored by the three following countries: Germany (42), USA (37) and Japan (33). The current output is about 50 dossiers per year (70-100 CAS-No), but a trend for an increase of output is noticeable. Industry, national authorities, and OECD work on a further development to speed up the output. The number of chemicals with 'low priority for further work' and the work recommended for the 'candidates' (mainly exposure assessment) indicate that the data presented were adequate for an initial hazard assessment according to OECD requirement