Effect of the Ascorbic Acid Treatment on the NADHd-Positive My enteric Neurons of Diabetic Rats Proximal Colon

摘要

The aim of this work was to study the effect of the ascorbic acid on the my enteric neurons of diabetic rats proximalcolon. Fifteen rats (90 days old) were divided into three groups: control, untreated diabetic and treated diabeticwith ascorbic acid (DA). After 120 days of daily treatment with ascorbic acid, the intestinal segments weresubmitted to the NADH-diaphorase (NADHd) histochemistry technique to expose the myenteric neurons. The groupDA showed a higher neuronal density (33.4 %) when compared to the untreated diabetic animals (p < 0.05).Cellular body area of neurons was significantly larger in group DA (17.3 %) when compared to the untreateddiabetics (p < 0.05). It could be concluded that the ascorbic acid promoted a neuroprotective effect on the NADHdmyenteric neurons of the proximal colon of diabetic rats.