Interaction of N-(2-hydroxybenzyl)-ω-amino carbonic acids, novel amphipathic fatty acid derivatives, with membrane: partition coefficients

摘要

The methods for partition coefficient (Kp) determination were developed for different concentrations of N-(2-hydroxybenzyl)-ω-amino carbonic acids, a new class of amphipathic fatty acid derivatives (An), their deutero (AnD) and bromine (AnBr) derivatives. To do this the following methods were used: 2H-NMR, equilibrium dialysis, centrifugation and fluorescence spectroscopy. Kp dependence on the An concentration is discussed. Kp values for AnBr were more than 120-times higher than those for An, the differences between them being smaller than those for the corresponding A n. This series of new amphipathic compounds can be used as probes for membrane studies.