首页> 外文期刊>Environmental health perspectives. >Effects of Atrazine on Estrogen Receptor alpha- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts
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Effects of Atrazine on Estrogen Receptor alpha- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts

机译:阿特拉津对雌激素受体α-和G蛋白偶联受体30介导的癌细胞和癌相关成纤维细胞信号传导和增殖的影响

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摘要

BACKGROUND: The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells. The G protein estrogen receptor (GPR30/GPER) has been reported to be involved in certain biological responses to endogenous estrogens and environmental compounds exerting estrogen-like activity.
机译:背景:农药r去津不会结合或激活经典的雌激素受体(ER),但会上调雌激素敏感性肿瘤细胞中的芳香化酶活性。据报道,G蛋白雌激素受体(GPR30 / GPER)参与了对内源性雌激素和发挥雌激素样活性的环境化合物的某些生物学反应。

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