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Cancer risk disparities between hispanic and non-hispanic white populations: the role of exposure to indoor air pollution.

机译:西班牙裔和非西班牙裔白人人口之间的癌症风险差异:暴露于室内空气污染中的作用。

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BACKGROUND: Hispanics are the fastest growing minority group in the United States; however, minimal information is available on their cancer risks from exposures to hazardous air pollutants (HAPs) and how these risks compare to risks to non-Hispanic whites. METHODS: We estimated the personal exposure and cancer risk of Hispanic and white adults who participated in the Relationships of Indoor, Outdoor, and Personal Air (RIOPA) study. We evaluated 12 of the sampled volatile organic compounds and carbonyls and identified the HAPs of most concern and their possible sources. Furthermore, we examined sociodemographic factors and building characteristics. RESULTS: Cumulative cancer risks (CCRs) estimated for Hispanics (median = 519 x 10(-6), 90th percentile = 3,968 x 10(-6)) and for whites (median = 443 x 10(-6), 90th percentile = 751 x 10(-6)) were much greater than the U.S. Environmental Protection Agency (EPA) benchmark of 10(-6). Cumulative risks were dominated by formaldehyde and p-dichlorobenzene (p-DCB) and, to a lesser extent, by acetaldehyde, chloroform, and benzene. Exposure to all of these compounds except benzene was primarily due to indoor residential sources. Hispanics had statistically higher CCRs than did whites (p
机译:背景:西班牙裔是美国增长最快的少数族裔。然而,关于其暴露于有害空气污染物(HAP)的癌症风险以及这些风险与非西班牙裔白人风险相比的信息很少。方法:我们估算了参加室内,室外和个人空气(RIOPA)关系研究的西班牙裔和白人成年人的个人暴露和癌症风险。我们评估了采样的12种挥发性有机化合物和羰基化合物,并确定了最受关注的HAP及其可能的来源。此外,我们研究了社会人口统计学因素和建筑特征。结果:西班牙裔(中位数= 519 x 10(-6),第90个百分位数= 3,968 x 10(-6))和白人(中位数= 443 x 10(-6),第90个百分位数=)估计的累积癌症风险(CCR) 751 x 10(-6))比美国环境保护局(EPA)的10(-6)基准要大得多。累积风险主要由甲醛和对二氯苯(p-DCB)决定,在较小程度上由乙醛,氯仿和苯决定。除苯外,所有这些化合物的暴露主要是由于室内住宅的原因。据统计,西班牙裔美国人的CCRs高于白人(p≤0.05),这是因为对pDCB,氯仿和苯的接触差异。甲醛是CCR的最大贡献者,占69%的西班牙裔和88%的白人。在通风率较低的房屋中,室内污染物排放的癌症风险增加。结论:西班牙裔似乎受到来自室内和室外来源的某些HAP的不成比例的影响。旨在降低整个人口和整个人口子群接触HAP的风险的政策应考虑室内空气污染。

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