Effect of Acute and Moderate Repeated Stress on Disturbances in Reactivity of Mesenteric Lymphatic Vessels during Inflammation in Rats

摘要

We studied the effect of acute (single immobilization for 1 h) and repeated (daily immobilization for 1 min, 5 days) moderate stress on disturbances in contractility of mesenteric lymphatic vessels in rats with experimental peritonitis. Acute stress was shown to potentiate, while moderate repeated stress attenuate the effect of inflammatory stimulus. It can be hypothesized that moderate repeated stress improves adaptive capacities of the organism, which manifests in reduction or prevention of dysfunction in contractile activity of lymphatic vessels.Chronic and severe stress can induce serious disturbances in various systems of the organism, which results in the development of diseases. The pathogenesis of these diseases is often associated with the inflammatory process. Strong evidence exists that stress exposure increases susceptibility of the organism to inflammatory agents. These changes are related to the exhaustion of stress-liming systems and reduced release of anti-inflammatory mediators [4,5]. However, moderate and short-term stress can activate the endogenous protective mechanisms improving organism's resistance to subsequent exposure to adverse factors [6].-For example, repeated restraint stress has a strong inhibitory effect on vascular endothelial permeability (major component of the inflammatory response) [9]. Pre-exposure to moderate stress prevents gastric ulceration in rats under conditions of severe stress [10].