The D-batable Institute of Medicine report: a D-lightful perspective.

摘要

During the past decade, several thousand articles have been written about the health benefits of vitamin D and sun exposure (1-4). Being born or living at lower latitudes and being exposed to more sunlight reduces the risk of type 1 diabetes mellitus, multiple sclerosis, hypertension, and dying of cancer. Numerous studies have reported an inverse association with vitamin D status, ie, lower serum 25-hydroxyvitamin D (25[OH]D) levels are associated with increased risk for cancers of the breast, prostate, and colon among others; type 2 diabetes mellitus; cardiovascular disease; multiple sclerosis; rheumatoid arthritis; osteo-arthritis; preeclampsia; cesarean delivery; depression; Alzheimer disease; infectious diseases; and neurocognitive dysfunction (1-5). However, because these studies were association and observational studies, they were dismissed by the recent Institute of Medicine (IOM) report on dietary reference intakes (6) as not qualifying as a high enough level of evidence to confirm the beneficial effect of vitamin D on these nonskeletal-related health outcomes.