Effect of Deprenyl on Free Radical Oxidation in Rat Brain during Immobilization Stress

摘要

Rarely repeated episodes of 1-h immobilization in rats were accompanied by an increase in the content of molecular products of lipid peroxidation and decrease in the amount of oxida-tively modified proteins. Monoamine oxidase B inhibitor deprenyl prevented the poststress activation of lipid peroxidation.Free radical oxidation is involved in the pathogenesis of vascular and neurodegenerative diseases and plays a role in the development of age-related injury to the central nervous system (CNS) [3,5,7]. Previous studies showed that monoamine oxidase B (MAO-B) inhibitor deprenyl reduces the severity of oxidative stress and produces a neuroprotective effect during Alzheimer's disease [12]. A relationship exists between the content of molecular products of lipid peroxidation (LPO) and activity of MAO-B in human CNS during postnatal ontogeny [5,6]. Published data show that similar variations are observed during rarely repeated episodes of 1-h immobilization (RRIM) [10]. These data suggest that activation of LPO in the brain is a MAO-B-depen-dent process. Here we tested this hypothesis.