Regulatory Role of Supramolecular Alcohol Dehydrogenase and Lactate Dehydrogenase Complex in Cell Mitochondria

摘要

The existence of a supramolecular alcohol dehydrogenase-lactate dehydrogenase complex was demonstrated. Enzyme activities were evaluated in a preparation of mitochondrial membranes from mouse liver. The role of the enzyme complex (alcohol dehydrogenase-lactate dehydrogenase) in the regulation of pyruvate and acetaldehyde metabolism in the cell was studied.The mechanisms regulating cell metabolism is a key problem of biochemistry. One of the priority tasks in this problem is comprehensive study of the pathways of metabolism regulation at different levels of organization: individual enzymes, multienzyme complexes, subcellular organelles, and the whole cell.