Effect of lauric acid on transdermal penetration of phenazepam in vivo.

Kravchenko IA; Golovenko NY; Larionov VB; Aleksandrova AI; Ovcharenko NV

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Effect of lauric acid on transdermal penetration of phenazepam in vivo.

机译：月桂酸对苯扎西m体内透皮渗透的影响。

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We studied the effect of lauric acid on transdermal penetration of phenazepam in vivo. It was found that treatment with lauric acid 3-fold increased the maximum anticonvulsive effect of phenazepam applied in a transdermal therapeutic system in comparison with the control. Study of the pharmacokinetics of phenazepam transdermal therapeutic system showed its higher bioavailability in the presence of lauric acid (f=0.9).

机译：我们研究了月桂酸对苯扎西m体内透皮渗透的影响。已经发现，与对照相比，用月桂酸治疗3倍增加了在透皮治疗系统中应用的非那西m的最大抗惊厥作用。吩西epa透皮治疗系统的药代动力学研究表明，在月桂酸存在下，其生物利用度更高（f = 0.9）。

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来源
《Bulletin of experimental biology and medicine 》 |2003年第6期| 共3页
作者
Kravchenko IA; Golovenko NY; Larionov VB; Aleksandrova AI; Ovcharenko NV;
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原文格式 PDF
正文语种 eng
中图分类基础医学 ;
关键词
phenazepam; lauric acid; in vivo; Therapeutic; Effective;

机译：吩西epa;月桂酸;体内;治疗;有效;

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1. Effect of lauric acid on transdermal penetration of phenazepam in vivo. [J] . Kravchenko IA, Golovenko NY, Larionov VB, Bulletin of experimental biology and medicine . 2003 ,第6期

机译：月桂酸对苯扎西m体内透皮渗透的影响。
2. Ion pair formation as a possible mechanism for the enhancement effect of lauric acid on the transdermal permeation of ondansetron. [J] . Dimas DA, Dallas PP, Rekkas DM Pharmaceutical development and technology . 2004 ,第3期

机译：离子对的形成可能是增强月桂酸对恩丹西酮透皮渗透作用的可能机制。
3. Effect of polyunsaturated fatty acids and some conventional penetration enhancers on transdermal delivery of atenolol. [J] . Puglia C, Bonina F Drug delivery. . 2008 ,第2期

机译：多不饱和脂肪酸和一些常规渗透促进剂对阿替洛尔透皮递送的影响。
4. Enzymatic synthesis of glycerol ester hydrolyzed coconut oil fatty acid and lauric acid as emulsifier and antimicrobial compound [C] . K. Sangadah, S. Handayani, S. Setiasih, International Symposium on Current Progress in Mathematics and Sciences . 2018

机译：糖醇酯水解椰子油脂脂肪酸和月桂酸的酶促合成作为乳化剂和抗微生物化合物
5. Sequential application of epsilon-polylysine, lauric arginate and acidic calcium sulfate for inactivation of pathogens on raw chicken and beef. [D] . Benli, Hakan. 2008

机译：依次使用ε-聚赖氨酸，精氨酸月桂酸酯和酸性硫酸钙灭活生鸡肉和牛肉上的病原体。
6. The Effect and Mechanism of Transdermal Penetration Enhancement of Fu’s Cupping Therapy: New Physical Penetration Technology for Transdermal Administration with Traditional Chinese Medicine (TCM) Characteristics [O] . Wei-Jie Xie, Yong-Ping Zhang, Jian Xu, 2017

机译：傅氏拔罐疗法的透皮渗透增强作用及其机理：具有中药特点的透皮给药新物理渗透技术
7. Transdermal delivery of theophylline using ethanol/water-hydroxypropylmethylcellulose systems with lauric acid. [O] . Shigeru Goto, Cheon Koo Lee, Akira Yagi, 1994

机译：利用乙醇/水 - 羟丙基甲基纤维素体系与月桂酸透皮递送茶碱。
8. Results of a Log Pow Measurement on the Reaction Product of 2-Hexyldecan-1-ol, 2-Octyldecan-1ol and Lauric acid. [R] . 2013

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Effect of lauric acid on transdermal penetration of phenazepam in vivo.

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