Selective glucocorticoid receptor modulators: future of glucocorticoid immunosuppressive therapy?

摘要

The second mechanism of transcriptional regulation acts by interference of the GR-monomer with other transcription factors and is independent of dimerization and DNA binding. Transrepression of proinflammatory modulators as nuclear factor kappaB and AP-1 inhibits the downstream inflammatory cascade and is traditionally considered to be the predominant mechanism regulating antiinflammatory actions of glucocorticoids (11-13).