Secondary extension of Hodgkin's disease to the skin with positive staining for EBV-encoded latent membrane protein.

摘要

Cutaneous involvement with Hodgkin's disease in HIV-positive patients is infrequent. Although the large majority of these cases are pathogenetically linked to Epstein-Barr virus, demonstration of viral oncogenes in skin involvement of Hodgkin's disease has rarely been performed. We report an HIV-positive male with aggressive Hodgkin's disease and specific cutaneous involvement. The presence of Epstein-Barr virus in cutaneous and lymph node samples could be demonstrated by a positive reaction to the Epstein-Barr virus latent-encoded membrane protein.