Conjunctival/Corneal Intraepithelial Neoplasia

摘要

Tumors of the squamous epithelium of the conjunctiva and cornea are the most common type of primary ocular neoplasms encountered in clinical practice around the world.Pizzarello and Jakobiec coined the term conjunctival intraepithelial neoplasia (CIN) in 1978. In CIN, the abnormal epithelium can be limited to the conjunctiva, the cornea, or involve both. When this disordered epithelial maturation involves the cornea, it is called corneal intraepithelial neoplasia. Corneal intraepithelial neoplasia was first described in 1984 by Waring et al. Conjunctival and corneal invasive neoplasia was described by Erie et al in 1986. However, the term epithelioma was used by von Graefe as early as the 1860s to describe squamous cell carcinoma of the conjunctiva and cornea.