Preparation and characterization of dinuclear copper -indomethacin anti-inflammatory drugs

摘要

The crystal and molecular structures of ternary copper -indomethacin complexes[Cu_2(Indo)_4L_2](IndoH=indomethacin=1-(chlorobenzoy)-5-methoxy-2-methyl)-1H -indole-3-acetic acid; L=acetonitrile (AN), N,N-dimethylacetamide (DMA), tetrahydrofuran (THF), or pyridine (Py) are reported. All four complexes contain a dinuclear 'Cu-acetate' molecular structure in which the carboxyl groups of the indomethacin ligands act ad bridges. The Cu-Cu distances of 2.469(3),2.6420(8), and 2.6784(8)A; Cu-O(Ac)_(av) distances o 1.964 A; and Cu-L distances of 2.132(6), 2.1805(17), and 2.177(2)A, respectively, for L=DMA, THF and Py, are typical of such distances in dinuclear complexes of the type. There are two independent complexes in the AN adduct with Cu_Cu distances of 2.6311 (11) and 2.6206(8) A; Cu-o(Ac)_(av) distances of 1.965 and 1.965 A; and Cu-L-(av) distances of 2.184 and 2.197 A, respectively. The pyridine complex exists mainly as a monomer in sollution, which may be associated with the longer Cu-Cu bond in this adduct as compared to the other complexes