1,1 '-bis(3-hydroxypropyl)ferrocene: Preparation and substitution with polyfluoroalkyl groups

摘要

SiMe3CH2CH2 was demonstrated as a robust and convenient OH protecting group in the preparation of 1,1'-bis(3-hydroxypropyl)ferrocene (1). The OH groups were used to introduce polyfluorinated alkyl chains by acylation of 1 with (C2F5CO)20 and alkylation with CF3(CF2)(6)CH2OH under Mitsunobu reaction conditions. This demonstrates a new method for introduction of an omega-hydroxyalkyl group to the Cp unit as a synthetic handle for modification of molecular properties. (c) 2007 Elsevier B.V. All rights reserved.