Causality Implies the Lorenz Group for Cryobiological 'Freezing-Drying' by the Vacuum Sublimation of Living Cells

摘要

From the new results by the contributions of the living cells and systems environmental "freezing-drying" and vacuum sublimation for the intracellular ice formation after sublimate condensation and the following vitrification of the living cells (Belaus, A. M., Ts. D. Tsvetkov, 1985, Zwetan D. Zwetkow, 1985, Tsvetkov et al., 1989, 2004, 2005, 2006, 2007) it is hopped that by the ice grate form and expressed e.g. by the thermodynamically and kinetic jump behavior of the living cells will be possibly to describe the biological expressions of the non equilibrium vitrified living cell state by means causality and Lorenz group too describing by quantum field theory. Freeze-drying or "lyophilization" is a drying process where the living cells environmental solvent is first frozen and then removed by sublimation under low pressure. The process consists of 3 main stages: freezing at a given time t, primary -and secondary drying for t implied by (t_(-2(n-1/2j), t_2(n-1/2j)]. After complete solidification inthe first stage at a time t = tau_j~L X~0, the shelf temperature is then at the time t = tau_j~L X~0+ 0 slightly increased to supply heat for the sublimation of ice and by the sublimate condensation for the formation of the vitrified living cell state.The secondary drying phase includes removing of water from solute phase by desorption usually at temperature above room temperature. So the primary drying step should be carried out at the highest temperature possible; wish is limited by the so called "maximum allowable temperature". This temperature indicates the eutectic temperature for a solute that crystallize to the ice grate of the living cell during freezing or the "leap temperature" for systems that remains in the non equilibrium vitrified state. Lyophilization is the most expensive at all drying operations, both in capital investment and in operation expenses. In this context the main theoretical focus in process development is to minimize consistly drying times, while maintaining constant preserved product quality. It is believed that for the studying of the living cells and systems the concept of the classical cryobiological non equilibrium thermodynamics and the axiomatic quantum field theory of the N. N. Bogolubov are sufficiently for thetheoretical consideration of the dynamic of cellular control processes. From a great interest is the so called problem of the connection between the entronv and the time arrow. With other words the connection in the cryobiology between the entropy and the causality according to quantum field theory of the interactions, the external conditions models between elementary cells and living cells with classical environmental biofields modeled by the additional boundary conditions by the vitrification obtained e.g. as by the Casimir effect. At the molecular level (Mitter and Robaschik, 1999) the thermodynamic behavior is considered by any electromagnetic quantum field with additional boundaries as by the Casimir effect between the two parallel, perfectly conducting square plates (side L, distance d, L > d), embedded in a large cube (side L) with one of the plates at face an periodic boundary condition. It is considered contributions from the volume L~2d between the plates resp. L~2 (L-d) outside have different temperature (outside T', inside T). For the temperatures T'< T, the external pressure is reduced in comparison with the standard situation (T' = T). Therefore it is expected the existence of a certain distance d_0, at which the Casimir attraction iscompensated by the net radiation pressure.