Modern dosimetric tools for (60)Co irradiation at high containment laboratories.

摘要

PURPOSE: To evaluate an innovative photo-fluorescent film as a routine dosimetric tool during (60)Co irradiations at a high containment biological research laboratory, and to investigate whether manufacturer-provided chamber exposure rates can be used to accurately administer a prescribed dose to biological specimens. MATERIALS AND METHODS: Photo-fluorescent, lithium fluoride film dosimeters and National Institutes of Standards and Technology (NIST) transfer dosimeters were co-located in a self-shielded (60)Co irradiator and exposed to gamma-radiation with doses ranging from 5-85 kGy. Film dose-response relationships were developed for varying temperatures simulating conditions present when irradiating infectious biological specimens. Dose measurement results from NIST transfer dosimeters were compared to doses predicted using manufacturer-provided irradiator chamber exposure rates. RESULTS: The film dosimeter exhibited a photo-fluorescent response signal that was consistent and nearly linear in relationship to gamma-radiation exposure over a wide dose range. The dosimeter response also showed negligible effects from dose fractionization and humidity. Significant disparities existed between manufacturer-provided chamber exposure rates and actual doses administered. CONCLUSION: This study demonstrates the merit of utilizing dosimetric tools to validate the process of exposing dangerous and exotic biological agents to gamma-radiation at high containment laboratories. The film dosimeter used in this study can be utilized to eliminate potential for improperly administering gamma-radiation doses.