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Polymerized rosin: novel film forming polymer for drug delivery.

机译:聚合松香:用于药物输送的新型成膜聚合物。

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摘要

Polymerized rosin (PR) a novel film forming polymer is characterized and investigated in the present study for its application in drug delivery. Films were produced by a casting/solvent evaporation method from plasticizer free and plasticizer containing solutions. Films prepared from different formulations were studied for their mechanical (tensile strength, percent elongation and Young's modulus), water vapour transmission and moisture absorption characteristics. Neat PR films were slightly brittle and posed the problem of breaking during handling. Hydrophobic plasticizers, dibutyl sebacate and tributyl citrate, improved the mechanical properties of free films with both the plasticizers showing significant effects on film elongation. Release of diclofenac sodium (model drug) from coated pellets was sustained with high coating levels. Concentration of plasticizer was found to affect the release profile. PR films plasticized with hydrophobic plasticizers could therefore be used in coating processes for the design of oral sustained delivery dosage forms.
机译:聚合松香(PR)新型成膜聚合物的特征和本研究中研究其在药物传递中的应用。通过流延/溶剂蒸发法由不含增塑剂和含增塑剂的溶液生产薄膜。研究了由不同配方制备的薄膜的机械性能(拉伸强度,伸长率和杨氏模量),水蒸气透过率和吸湿特性。整齐的PR膜稍脆,并在处理过程中出现断裂问题。疏水性增塑剂,癸二酸二丁酯和柠檬酸三丁酯,改善了游离薄膜的机械性能,这两种增塑剂均对薄膜的伸长率具有显着影响。高包衣水平持续从包衣小丸中释放双氯芬酸钠(模型药物)。发现增塑剂的浓度影响释放曲线。因此,用疏水增塑剂增塑的PR膜可用于包衣过程中,以设计口服持续递送剂型。

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