Pathological Remodeling of Myocardium in Spontaneous Hypertensive Rats with Experimental Diabetes Mellitus: Role of Mitochondrial Dysfunction

摘要

The expression of cardiotrophin-1, annexin V, titin and type I collagen was investigated in the myocardium of normotensive Wistar rats and spontaneous hypertensive rats with experimental diabetes and without it. The Ca~(2+) -induced mitochondrial permeability transition pore was assessed in the mitochondria isolated from rat hearts. The content of cardiotrophin-1, annexin V and type I collagen in spontaneous hypertensive rats with diabetes was higher compared to normotensive and diabetic rats. The cardiac titin level was 27% lower in animals with hypertension and diabetes compared with spontaneous hypertensive rats without diabetes. The changes in cardiotrophin-1, annexin V, titin and type I collagen expression were associated with higher sensitivity of mitochondrial pore to Ca~(2+) in the myocardium of spontaneous hypertensive rats with diabetes mellitus.