The Content of Blood Leptin and Activity of Systemic Inflammatory Response in Patients with Type 2 Diabetes Mellitus depending on Weight and Length of the Process

摘要

The aim of the study was to establish the relationship between the blood leptin content and the markers of generalized non-specific inflammation in patients with type 2 diabetes mellitus (DM), depending on its duration, excess weight and obesity. We compared the contents of leptin, interleukins (IL) IL-2, IL-6, and tumor necrosis factor a (TNF-a) in groups with different duration of type 2 diabetes mellitus, in normal, overweight, and obese patients. In the patients with high leptin content, significantly lower levels of TNF-a (7.82 ± 0.34 ng / ml) have been found. The positive correlation of the latter with body mass index (r = 0.48, P < 0.0001) and IL-6 (r = 0.13, P = 0.019) was observed, resulting from the increased pool of visceral adipose tissue that produces leptin and 10 - 35% of IL-6. In patients with newly diagnosed type 2 diabetes mellitus, the levels of leptin (19.35 ± 1.39 ng / ml) and TNF-a (7.82 ± 0.94 ng / ml) were significantly lower compared to the control values. The highest contents of leptin and cytokines were observed in the patients with diabetes duration of 5 to 10 years. As a rule, cardiovascular complications are developed just in this period. In the group of patients with normal weight, the contents of leptin (6.39 ±1.15 ng / ml) were the lowest, whereas the contents of TNF-a (11.37 ± 3.77 ng / ml) and IL-6 (10.12 ± 6.91 ng / ml) were the highest. Perhaps it is the high content of these cytokines that makes it possible to maintain a normal body weight in these patients. It is known that under prolonged glucose - and lipotoxicity metabolic immunosuppression emerges, defined by the changes in T-cell immunity, which also contributes to autoimmunity in type 2.diabetes mellitus.