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Genomic epidemiology of prostate cancer, family history approach, and the adoption of socio-ecological model to increase screening among American adult males

机译:前列腺癌的基因组流行病学,家族史方法以及采用社会生态学模型以增加美国成年男性的筛查

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This project compared the deadly impact of prostate cancer in African-Americans and Caucasians and identified the gene-chromosomes which serve as precursors for this type of cancer. Innovative genomic techniques for screening and detecting prostate cancer were discussed. A comprehensive family history approach for screening at risk family members was illustrated. The succinct rationales for the socio-ecological model were presented and the relevance for screening using this model was critically analysed. To ensure that patients receive the precise chemotherapy, the concept of pharmacogenomics was presented as mechanism to ensure that the correct drug is administered in the right dose, at the right time to patients of different ethnic groups, based on their specific DNA sequence in order to avoid the onset of imperfect specificity and iatrogenic diseases. A comprehensive analysis of precision medicine which consists of predictive, preventive, personalised, and participatory innovative approach in genomic medicine was presented. Molecular science was predicted to enable oncologists to maximise treatment effectiveness while avoiding potentially life-threatening side-effects.
机译:该项目比较了前列腺癌对非裔美国人和高加索人的致命影响,并确定了作为此类癌症前体的基因染色体。讨论了筛选和检测前列腺癌的创新基因组技术。说明了用于筛查高危家庭成员的综合家族史方法。提出了简洁的社会生态模型论据,并严格分析了使用该模型进行筛查的相关性。为了确保患者接受精确的化疗,提出了药物基因组学的概念,以确保根据他们的特定DNA序列,在正确的时间,正确的时间对不同种族的患者以正确的剂量给予正确的药物,以便避免出现不完全的特异性和医源性疾病。提出了对精密医学的全面分析,其中包括对基因组医学的预测,预防,个性化和参与性创新方法。据预测,分子科学将使肿瘤科医生能够最大程度地提高治疗效果,同时避免潜在的威胁生命的副作用。

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