Large Scale Genomic Approach to Prostate Cancer Risk in African- American Men

摘要

We are studying how genetic variation impacts sporadic prostate cancer risk in a multiethnic cohort with a particular emphasis on African American men. During the funding period, we have performed candidate gene and genome wide studies. Our candidate gene studies have focused on genes with a high likelihood of influencing prostate cancer and have been some of the largest and most thorough studies yet performed. We have demonstrated that: (a) the androgen receptor, insulin like growth factor binding proteins 1 and 3 do not demonstrate a significantly increased risk of prostate cancer, (b) variation at the insulin like growth factor 1 locus does contribute to increased risk. We have also performed the first genome wide admixture scan. We demonstrated that the average proportion of African ancestry is slightly, but significantly higher in cases than controls. We were unable, however, to conclusively identify a locus that accounted for the excess risk of prostate cancer in African American men. Our comprehensive and thorough approaches set the stage for better understanding how our genetic heritage influences prostate cancer risk.